Cefaclor Alternatives: Effective Antibiotics When Cefaclor Isn't Right

When Cefaclor, a second-generation cephalosporin antibiotic used to treat bacterial infections like ear infections, sinusitis, and bronchitis. Also known as cefaclor monohydrate, it's often prescribed when penicillin won't work—but not everyone can take it. If you're allergic, had bad side effects, or your infection isn't clearing up, you need options. Cefaclor isn't the only antibiotic that works for these common bugs. Many doctors turn to other drugs that are just as effective, sometimes even better tolerated.

One of the most common replacements is amoxicillin, a penicillin-class antibiotic that’s first-line for many respiratory and ear infections. It’s cheaper, widely available, and works well against the same bacteria Cefaclor targets. If you can’t take penicillin, then cefuroxime, a slightly stronger cephalosporin that’s often used when Cefaclor fails or isn’t suitable becomes the go-to. It’s more potent against certain resistant strains and works for more complicated infections. For people who need something oral but not a cephalosporin at all, azithromycin, a macrolide antibiotic that’s great for those with penicillin allergies and often used for sinus and lung infections is a solid pick. It’s taken less often—sometimes just once a day for three days—and has fewer stomach issues.

Other options like doxycycline or clarithromycin come up too, especially if the infection is tied to atypical bacteria or if there’s a history of antibiotic resistance in your area. The right choice depends on your age, allergies, past reactions, and what bacteria are likely causing the problem. You don’t just swap one pill for another—you match the drug to the bug and your body. That’s why it’s never a good idea to self-prescribe. But knowing what’s out there helps you ask the right questions when your doctor says, "Cefaclor didn’t work."

Below, you’ll find real comparisons of these and other antibiotics—what works, what doesn’t, and which ones people actually report feeling better on. No fluff. Just clear, practical info from real cases and studies.